Safety and efficacy of thrombolysis in telestroke: A review

imgresNeurology. 2016 Aug 26. pii: 10.1212/WNL.0000000000003148. [Epub ahead of print]



The aim of this systematic review and meta-analysis was to evaluate the safety and efficacy of IV thrombolysis (IVT) with tissue plasminogen activator (tPA) delivered through telestroke networks in patients with acute ischemic stroke.


We conducted a systematic review and meta-analysis according of prospective randomized controlled and nonrandomized studies comparing telemedicine-guided IVT to IVT administered at stroke centers and were published from the earliest date available until April 1, 2015.

  • Outcomes of interest were symptomatic intracerebral hemorrhage,
  • mortality, and functional independence (modified Rankin Scale scores 0-1) at 3 months.


  •  1,863 patients fulfilled our eligibility criteria.
  • Among these, thrombolysis was largely restricted to the 3-hour time window.
  • Symptomatic intracerebral hemorrhage rates were similar between patients subjected to telemedicine-guided IVT and those receiving tPA at stroke centers
  •  There was no difference in mortality or in functional independence  at 3 months between telemedicine-guided and stroke center thrombolysis.


Our findings indicate that IV tPA delivery through telestroke networks is safe and effective in the 3-hour time window. Lack of prospective trials, however, emphasizes the need to further substantiate these findings in the 3- to 4.5-hour time window.

© 2016 American Academy of Neurology.

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C3O Telemedicine News

Posted on:
September 3rd, 2016

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